Home About us Editorial board Current issue Search Archives Submit article Instructions Subscribe Contact Us Login 
An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2016  |  Volume : 20  |  Issue : 3  |  Page : 467-473
Immunohistochemical analysis of angiogenesis by CD34 and mast cells by toluidine blue in different grades of oral squamous cell carcinoma

1 Department of Oral Pathology and Microbiology, P.M.N.M. Dental College and Hospital, Bagalkot, Karnataka, India
2 Department of Oral Pathology and Microbiology, A.J Institute of Dental Sciences, Mangalore, Karnataka, India
3 Department of Oral Pathology and Microbiology, College of Dental Sciences, Davangere, Karnataka, India
4 Department of Oral Pathology and Microbiology, Subbaiah Dental College, Shimoga, Karnataka, India

Correspondence Address:
Pramod Sangamesh Ingaleshwar
Department of Oral Pathology and Microbiology, P.M.N.M. Dental College and Hospital, Bagalkot, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.190950

Rights and Permissions

Introduction: Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. Objectives: The present study was conducted to compare microvessel density (MVD) and mast cell density (MCD) in different histological grades of OSCC in comparison with normal oral mucosa (NM). Materials and Methods: Comparison of MVD by CD34 and MCD by toluidine blue among different histological grades of OSCC and in NM as controls. Statistical Analysis : The results were analysed using ' t" test, ANOVA and Pearson's correlation co-efficient. Results: The mean MVD was higher in different grades as compared to normal mucosa. Intergroup comparison of increase in MVD between different grades of OSCC was not found to be highly statistically significant. Pearson's correlation between MVD and MCD revealed a linear increase in MVD as the MCD increased, suggestive of a positive correlation. Conclusion: There was significant correlation found between MVD and MCD which was in agreement that mast cells promote tumor progression through upregulation of angiogenesis.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded97    
    Comments [Add]    

Recommend this journal


Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007