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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
REVIEW ARTICLE Table of Contents   
Year : 2014  |  Volume : 18  |  Issue : 4  |  Page : 90-95
Second malignancies in Hodgkin's disease: A review of the literature and report of a case with a secondary Lennert's lymphoma


Department of Diagnostics, University of the Western Cape, Tygerberg, South Africa

Correspondence Address:
Erich J Raubenheimer
Department of Pathology, School of Oral Health Sciences, University of Limpopo, 0204
South Africa
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.141332

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A small percentage of patients treated for Hodgkin's disease are at risk of developing a second malignancy. The appearance of secondary malignancies such as leukemia, carcinoma or non-Hodgkin's lymphomas may be attributed to the mutagenic effects of chemotherapy and/or radiotherapy. Most secondary non-Hodgkin's lymphomas are of the B-cell type, but isolated cases were reportedly of a T-cell lineage. A review of the literature pertaining to the development of secondary peripheral T-cell lymphomas is presented along with the description of an additional case. The latter developed in the tonsil and was diagnosed as a Lennert's lymphoma (lymphoepithelioid T cell lymphoma)on histological and immunological grounds. This report also reviews the development of a of peripheral T-cell lymphoma described in patients following chemotherapy and/or radiotherapy for Hodgkin's disease


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