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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
  Table of Contents    
CASE REPORT  
Year : 2014  |  Volume : 18  |  Issue : 4  |  Page : 157-162
 

Dens invaginatus (dilated odontome) in mandibular canine


Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India

Date of Submission01-Sep-2014
Date of Acceptance09-Sep-2014
Date of Web Publication20-Sep-2014

Correspondence Address:
GVV Satyakiran
Post Graduate Student, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Sir MVIT Campus, Off International Airport Road, Hunasamaranahalli via Yelahanka, Bangalore - 562 157, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.141379

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   Abstract 

Dens invaginatus is a developmental malformation of teeth related to shape of the teeth. Affected teeth show a deep infolding of enamel and dentin starting from the tip of the cusps and may extend deep into the root. It results from the invagination of the enamel organ into the dental papilla before calcification has occurred. Teeth most affected are maxillary lateral incisors. The presence of dens invaginatus in mandibular canine is extremely rare. The tooth was symptomatic in that it was mobile and was oriented horizontally. This article presents a case of symptomatic dens invaginatus in mandibular canine.


Keywords: Dens in dente, dilated composite odontome, mandibular canine


How to cite this article:
Halawar SS, Satyakiran G, Krishnanand P S, Prashanth R. Dens invaginatus (dilated odontome) in mandibular canine . J Oral Maxillofac Pathol 2014;18, Suppl S1:157-62

How to cite this URL:
Halawar SS, Satyakiran G, Krishnanand P S, Prashanth R. Dens invaginatus (dilated odontome) in mandibular canine . J Oral Maxillofac Pathol [serial online] 2014 [cited 2019 Oct 20];18, Suppl S1:157-62. Available from: http://www.jomfp.in/text.asp?2014/18/4/157/141379



   Introduction Top


Dens invaginatus (DI) is a developmental anomaly resulting from the invaginations of the coronary or root surface of the enamel organ into dental papilla before calcification occurs. [1],[2],[3],[4]

This anomaly was first described by Ploquet in 1794 in a whale's tooth. It was subsequently described by Socrates in human tooth in 1856. [5] In 1873 Mühl Reiter reported on 'anomalous cavities in human teeth', Baume in 1874 and Busch in 1897 published on this malformation. [1],[2]

Diverse synonyms given to this anomaly and reason for which it is called so [Table 1]. The most appropriate term to use would be 'dens invaginatus' as it reflects the infolding of the outer portion (enamel) into the inner portion (dentin) with the formation of a pocket and dead space. [1],[2]

Depending upon the degree of invagination, Oehlers FA (1957) has classified Dens-in-dente as [5]
Table 1: Synonyms for Dens invaginatus[1,2,5]

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  • Type I: Invagination confined to crown
  • Type II: Invagination extending beyond cementoenamel junction (CEJ). Large invaginations may become dilated and contain dystrophic enamel in the base of dilation
  • Type III: Invagination extending beyond CEJ penetrating the root and exhibiting a second foramina in the apical third.


The prevalence of DI ranges from 0.04-10%. [2]

The study conducted by Cakici et al., (2010) in a sample size of 1012. Full-mouth surveys concluded that the frequency of DI was 1.3% and most commonly observed was type I DI (81.25%). [2]

Authors have put forth various theories to describe the etiology of this anomaly [Table 2]. Most authors, meanwhile consider DI as a deep folding of the foramen cecum (or may start from incisal edge of the tooth) during tooth development which in some cases may result in a second apical foramen (Schulze, 1970). Generic factors cannot be excluded. (Grahnen, 1962, Casamassiomo et al., 1975, Ireland et al., 1987, Hosey and Bedi, 1996). [6]
Table 2: Theories proposed to describe the etiology of dens invaginatus[1,2,7,8]

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The teeth most affected are permanent maxillary lateral incisors followed by maxillary central incisors, premolars, canines and less frequently in the molars. Bilateral occurrence is not uncommon and occurs in 43% of all cases. The posterior teeth are less likely to be affected. The female to male predilection is 3:1. [2],[9],[10]

Here we present a case of unilateral type 2 dens-in-dente in the mandibular canine. The tooth was mobile and was oriented horizontally, thus being symptomatic.


   Case report Top


A 53-year-old female patient reported to our outpatient department seeking treatment for her mobile tooth. No other abnormalities were noted.

On clinical examination, Extra-oral findings were unremarkable.

Intra oral examination showed grade III mobility Interim restorative treatment (IRT) to 43 (Right mandibular canine), spacing between 43 and 44 and horizontal orientation of 43.

Radiographic examination revealed well circumscribed radiopaque - radiolucent mass, surrounded by a zone of radiolucency and a sclerotic border separating the basal bone in the region of 43 [Figure 1]. The tooth was extracted under local anesthesia and subjected to histopathological examination.
Figure 1: Orthopantomogram reveals well circumscribed radiopaque – radiolucent mass, surrounded by a zone of radiolucency and a sclerotic border separating the basal bone in the region of 43

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Grossing

On grossing, a hard tissue tooth specimen measuring 2.5 × 2 cm, creamish white in color, oval in shape was obtained. The specimen showed a smooth outline of crown and root of a canine tooth labially. Lingually, the tooth looked dilated in mesiodistal direction starting from cingulam till the root apex with an irregular surface [Figure 2]a-c.
Figure 2: Grossing specimen of the hard tooth specimen showing (a) Labial surface (b) Incisal surface (c) Lingual surface

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The specimen was cut into two equal halves in labio-lingual direction using metal disc, The cut specimen revealed dilated central core containing amorphous debris. The invagination seemed to have encroached the pulpal space which has been reduced to slit like spaces around the invagination. (Somaes and sothoum) [Figure 3] .
Figure 3: Gross specimen cut into two halves in labiolingual direction. The cut specimen show central core containing amorphous debris

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One half of the specimen was taken for ground section and the other was subjected to decalcification and routine processing.

Ground section

Examination of the ground section under the microscope revealed a dilated tooth specimen [Figure 4]a with an outer and inner layer of enamel. The dentin between the two zones was normal [Figure 4]b. The dilation extended from the cingulum area to the apical one third of the root. No communication with the periapical region was detected. The area of dilation which was previously occupied by amorphous debris, before ground sectioning, was lost. The base of the dilation was lined by both enamel and cellular cementum [Figure 4]c. On either side of the dilation, pulpal space was appreciated surrounded by well-formed dentin with dentinal tubules. The outer enamel was well- formed with incremental lines, enamel spindles, enamel lamellae and fish scale pattern of enamel was observed [Figure 4]c and e. A well formed dentino-enamel junction could also be appreciated. The enamel that lined the dilated space was amorphous. Most of the inner enamel did not reveal any incremental lines. The lining of the enamel close to the cingulum showed dentino-enamel junction (DEJ), but as it approached the root apex the DEJ distinguishing enamel and dentin was not appreciated [Figure 4]f.
Figure 4: (a) Ground section shows a central dilated area with dentin surrounded by pulp space (b and c): Ground section revealed an outer layer of enamel with incremental lines of Retzius, enamel lamellae and well formed DEJ around the central space. The inner wall of the dilation has haphazardly arranged amorphous material and lacked any incremental lines with dentin between the two layers (x100) (d) Ground section showing dilated space lined by both cellular cementum and enamel (x200) (e) Ground section revealing outer layer of enamel showing fish scale pattern (x400) (f) The inner layer of enamel without DEJ

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Decalcified section

Examination of the hematoxylin and eosin (H and E) section under microscope revealed dentin made up of several dentinal tubules in cross section [Figure 5]a and invaginated portion of the tooth lined by dentin [Figure 5]b. Focal areas show cementodentinal junction with clear dentin and acellular cementum on the ether sides [Figure 5]b. Focal areas of pulpal spaces surrounded by dentin were also evident [Figure 5]d.
Figure 5: (a) Decalcified section revealed dentin made up of several dentinal tubules in cross section (H&E, x200) (b) Decalcified section showing areas of enamel covering dentin on ether sides and invagination of the enamel in the central area (H&E, x100) (c) Decalcified section showing focal areas of cementodentinal
junction with clear dentin and acellular cementum on the ether sides (H&E, x100) (d) Decalcified section showing focal areas of pulpal spaces surrounded by dentin (H&E, x100)


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Based on the above ground section features along with decalcified sections a diagnosis of type 2 dens-in-dente was given.


   Discussion Top


DI is a developmental malformation of teeth. Affected teeth show deep infolding of enamel and dentin starting from the tip of the cusps or incisal edges and which may extend deep into the root. Which was seen in our case. The prevalence of DI ranges from 0.04-10%.

Clinically, a morphologic alteration of the crown (dilated, peg-shaped, barrel-shaped) or a deep foramen cecum can serve as an indication for the diagnosis of DI. [11] But, most cases of DI are detected after a routine radiographic evaluation with a panoramic X-ray and confirmed with a periapical film. [6],[11] Upon detection of DI in one tooth the contralateral tooth should also be examined as bilateral occurrence of this anomaly have been reported. [1],[2]

Classification of dens invaginatus [1],[2],[12]

DI has been classified into the following types according to the depth of the invagination and the degree of communication with the periodontal ligament or the periradicular tissue [Figure 6].
Figure 6: (a) Schematic diagrams of Dens invaginatus : Type I, (b) Dens invaginatus: Type II, (c) Dens invaginatus: Type II, (d) Dens invaginatus: Type III

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Type I: An enamel-lined invagination occurring within the confines of the crown not extending beyond the cemento-enamel junction.

Type II: An enamel-lined form which invades the root but remains confined as a blind sac. It may or may not communicate with the dental pulp.

Type III A: A form which penetrates through the root and communicates laterally with the periodontal ligament space through a pseudo-foramen. There is usually no communication with the pulp, which lies compressed within the root.

Type III B: A form which penetrates through the root, perforating at the apical area through a pseudoforamen. The invagination may be completely lined by enamel, but frequently cementum will be found lining the invagination.

Bhaskar describes two variations of DI as Coronal type and Radicular type.

The Coronal type is caused by an invagination of all layers of the enamel organ into the dental papilla. The pulp is usually exposed and becomes necrotic or inflamed. Not infrequently, periapical lesions are associated with this type, necessitating endodontic therapy.

In the Radicular type of DI there is a folding of Hertwig's sheath into the developing root, much like the coronal type. Associated pulpal necrosis and apical lesions are often noticed. [6]

Our case belongs to the Coronal type in which the enamel organ contents were seen extending into the root, but there was no pulp exposure. But tooth was symptomatic.

Radiographic features [1],[2],[11],[13],[14]

A radiopaque invagination, the density of which is equal to enamel can be seen extending from the coronal portion of the tooth usually the cingulum into the root canal. The invagination may vary in size and shape from being slightly radiolucent to loop-like to pear shaped to a dilated uniglobular mass. This invagination may end in coronal portion (Oehler's type I) extends into the root without any communication with the pulp (Oehler's type II) or may extend deep into the root canal opening through a lateral canal into the periapical region (Oehler's type III). The roots of the affected tooth may present smaller dimensions.

Histological findings [1],[2]

The enamel lining the invagination is continuous with that of the enamel lining the external surface. It is often defective and is poorly mineralized or absent in the areas particularly near the bottom of the cavity (Soames and Southam). The structure and thickness of the enamel lining the invagination also may vary widely. The enamel was described as irregularly structured by Atkinson (1943), Beynon (1982) and Piatelli and Trisi (1993). Beynon (1982) reported hypomineralized enamel at the base of the invagination whereas Morfis (1992), in a chemical analysis, detected up to eight times more phosphate and calcium with absence of magnesium when compared with the outer enamel. Bloch-Zupan et al., (1995) found differences in structure and composition between the external and internal enamel. The internal enamel exhibited atypical and more complex rod shapes and its surface presented the typical honeycomb pattern but no perikymata, which, however, were observed on the outer surface of the tooth.

The dentin below the invagination may be intact without irregularities (Brabant and Klees 1956, Omnell et al., 1960, Piatelli and Trisi, 1993) but also may contain strains of vital connective tissue (Omnell et al., 1960) or even fine canals with communication to the dental pulp (Kronfeld 1934, Fischer 1936, Hoepfel 1936, Gustafson and Sundberg 1950, Hitchin and McHugh 1954, Oehlers 1957a, Rushton 1958). Some authors reported hypomineralized or irregularly structured dentine (Omnell et al., 1960, Vincent-Townend, 1974, Beynon, 1982).

As the invagination impinges upon the pulp cavity the latter may be reduced to slit-like spaces around the sides of the invagination.

Clinical implication

The most significant clinical concern of DI is the risk of developing pulpal pathology. The invagination commonly communicates with the oral cavity, allowing the entry of irritants and microorganisms into the pulpal tissue which is separated by only a thin layer of enamel and dentin that may be hypomineralized. [7] This defect predisposes a tooth to dental caries and to subsequent pulpal pathologies.

Sometimes fine canals extend between the invagination and the pulp chamber, resulting in pulpal and periapical pathology even in the absence of dental caries. [1]

Upon radiographic evidence of DI, the apical periodontium should be examined because fine channels or cracks may run between the invagination and the pulp microorganisms may pass from oral cavity through DI into the pulp. [15]

Dental anomalies described in association with DI are microdontia, macrodontia, hypodontia, oligodontia, taurodontism, gemination and fusion, supernumerary teeth, dentinogenesis imperfecta, [15] amelogenesis imperfecta, invagination in an odontome, multiple odontomes, coronal agenesis, and Williams syndrome, dens evaginatus, talon's cusp, short roots. [13],[16]

Syndromic association of DI has been reported in Ekman-Westborg-Julin syndrome, Williams syndrome and Nance Huran syndrome. [9]

Treatment [5],[17],[18],[19],[20],[21]

Clinical management of these anomalies varies from case to case and is related to the degree of complexity of anatomy of the tooth. Treatment of DI ranges from conservative restoration of the opening to non-surgical endodontic treatment, endodontic surgery, intentional replantation, and finally extraction. Large and extremely dilated invaginations often have abnormal crowns and need to be extracted.

In cases in which there is an immature apex, the use of calcium hydroxide inside the root canal has been proposed to stimulate apexification.

 
   References Top

1.Hulsmann M. Dens invaginatus: Aetiology, classification, prevalence, diagnosis, and treatment considerations. Int Endod J 1997;30:79-90.  Back to cited text no. 1
    
2.Munir B, Tirmazi SM, Majeed HA, Khan AM, Iqbalbangash N. Dens invaginatus: Aetiology, classification, prevalence, diagnosis and treatment considerations. Pakistan Oral Dent J 2011;31:191-8.  Back to cited text no. 2
    
3.Rakes GM, Aiello AS, Kuster GC, Labart WA. Complications occurring resultant to dens invaginatus: Case report. Pediatr Dent 1988;10:53-6.  Back to cited text no. 3
    
4.Sousa Neto MD, Zuccolotto WG, Saquy PC, Grandini SA, Pécora JD. Treatment of dens invaginatus in a maxillary canine case report. Braz Dent J 1991;2:147-50.  Back to cited text no. 4
    
5.Neville BW. Abnormalities of teeth. In: Neville B, Damm DD, Allen CM, Bouquot J, editors. Oral and Maxillofacial Pathology. 2 nd ed. Philadelphia: W.B. Saunders; 2002. p. 80-2.  Back to cited text no. 5
    
6.Sisodia S, Maria R, Maria A. Dens invaginatus: A review and case report. Endodontology. Available from: http://medind.nic.in/eaa/t10/i2/eaat10i2p73.pdf.  Back to cited text no. 6
    
7.Pradeep K, Charlie M, Kuttappa MA, Rao PK. Conservative management of type III dens in dente using cone beam computed tomography. J Clin Imaging Sci 2012;2:51.  Back to cited text no. 7
    
8.Khanna S, Purwar A, Gulati R, Sharma D. Concurrence of dens invaginatus and evaginatus involving all maxillary anteriors: A rare case with comprehensive review. IOSR J Dent Med Sci 2013;6:59-62.  Back to cited text no. 8
    
9.Kallianpur S, Sudheendra S, Kasetty S, Joshi P. Dens invaginatus (Type III B). J Oral Maxillofac Pathol 2012;16:262-5.  Back to cited text no. 9
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10.Jaramillo A, Fernández R, Villa P. Endodontic treatment of dens invaginatus: A 5-year follow-up. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e15-21.  Back to cited text no. 10
    
11.Alani A, Bishop K. Dens invaginatus. Part 1: Classification, prevalence and aetiology. Int Endod J 2008;41:1123-36.  Back to cited text no. 11
    
12.Oehlers FA. Dens invaginatus. I. Variations of the invagination process and associated anterior crown forms. Oral Surg Oral Med Oral Pathol 1957;10:1204-18.  Back to cited text no. 12
    
13.Bansal AV, Bansal A, Kulkarni VK, Dhar RS. Dens invaginatus in primary maxillary molar: A rare case report and review of literature. Int J Clin Pediatr Dent 2012;5:139-41.  Back to cited text no. 13
    
14.White SC, Pharoah MJ. Oral radiology principles and interpretation. 4 th ed. St Louis: Mosby; 2000. p. 314-5.  Back to cited text no. 14
    
15.Zengin AZ, Sumer AP, Celenk P. Double dens invaginatus: Report of three cases. Eur J Dent 2009;3:67-70.  Back to cited text no. 15
    
16.Das A, Sivakumar K. A case of dens in dente in maxillary lateral incisor. J Indian Acad Dent Specialists 2010;1:47-8.  Back to cited text no. 16
    
17.Yadav M, Meghana SM, Kulkarni SR. Concommitant occurance of dens invaginatus and talon cusp: A case report. Rev Odonto Cienc 2011;26:187-90.  Back to cited text no. 17
    
18.Tagger M. Nonsurgical endodontic therapy of tooth invagination. Report of a case. Oral Surg Oral Med Oral Pathol 1977;43:124-9.  Back to cited text no. 18
    
19.Neves FS, Bastos LC, de Almeida MS, Bóscolo NF, Haiter-Neto F, Campos PS. Dens invaginatus: A cone beam computed tomography case report. J Health Sci Inst 2010;28:249-50.  Back to cited text no. 19
    
20.Szajkis S, Kaufman AY. Root invagination treatment: A conservative approach in endodontics. J Endod 1993;19:576-8.  Back to cited text no. 20
    
21.Ferguson FS, Friedman S, Frazetto V. Successful apexification technique in an immature tooth with dens in dente. Oral Surg Oral Med Oral Pathol 1980;49:356-9.  Back to cited text no. 21
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
 
 
    Tables

  [Table 1], [Table 2]



 

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