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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2014  |  Volume : 18  |  Issue : 2  |  Page : 211-216
Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma


1 Department of Oral Pathology, Burdwan Dental College, Burdwan, India
2 Department of Oral Pathology, Dr. R. Ahmed Dental College, Kolkata, West Bengal, India
3 Department of Oral Pathology, Gandhi Institute of Technology and Management Dental College, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Divya Uppala
S5, Meher Apartment, CBM Compound, VIP Road, Visakhapatnam 530 003, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.140752

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The prevalence of oral squamous cell carcinoma (OSCC) has significantly increased over decades in several countries and human papilloma virus (HPV) has been indicated as one of the underlying causes. This suggests that HPV plays a role in the early stages of carcinogenesis but is not a requisite for the maintenance and progression of malignant state. p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to HPV-induced carcinogenesis. The present study has been carried out to detect and correlate p53 polymorphism/mutation, HPV DNA in the biopsy samples of oral cancer patients who had tobacco habits.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007