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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2014  |  Volume : 18  |  Issue : 2  |  Page : 177-182
Evaluation of c-kit protein (CD117) expression in common salivary gland neoplasms


1 Department of Oral and Maxillofacial Pathology, Dental Research Centre, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Oral and Maxillofacial Pathology, Oral and Maxillofacial Diseases Research Centre, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Oral and Maxillofacial Radiology, Dental Research Centre, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran
5 Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Ala Ghazi
Department of Oral Medicine,School of Dentistry, Mashhad University of Medical Sciences, Vakilabad Blv, Mashhad 911735 984
Iran
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Source of Support: The results given in this paper were obtained from a postdoctoral research supported by the Vice Chancellor of Mashhad University of Medical Sciences, Iran., Conflict of Interest: None


DOI: 10.4103/0973-029X.140732

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Background: Adenoid cystic carcinoma (AdCC) is a malignant salivary gland neoplasm with poor long-term prognosis. Differentiating between AdCC and other salivary gland neoplasms can be a diagnostic challenge, particularly in examining tissues obtained from small incisional biopsies. Aim: The aim of this study was to evaluate c-kit expression in four common benign and malignant salivary gland neoplasms. Materials and Methods: Immunohistochemical techniques were used to analyze the level of c-kit expression in normal salivary gland (n = 10) and four different types of salivary gland tumors: Pleomorphic adenoma (PA) (n = 17), AdCC (n = 9), polymorphous low-grade adenocarcinoma (PLGA) (n = 4) and mucoepidermoid carcinoma (MEC) (n = 6). Samples were immunostained using monoclonal antibody against c-kit. Results: The immunoreactivity for c-kit was found in all cases of AdCC, PLGA and MEC and majority of PAs. Positive reactivity was observed in more than 50% of the tumor cells of AdCC and less than 50% in PLGA. PA did not show strong immunostaining and c-kit was predominantly localized to the cell membrane. Furthermore, the difference in the expression of c-kit between the benign and malignant neoplasms was not statistically significant. Conclusions: CD117 expression itself cannot be used as a marker in differential diagnosis of salivary gland neoplasms. However, the percentage of the CD117 immunoreactive cells and the staining intensities appeared to be important factors in distinguishing AdCC from PLGA and PA.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007