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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
REVIEW ARTICLE Table of Contents   
Year : 2014  |  Volume : 18  |  Issue : 1  |  Page : 52-57
Myofibroblasts in oral lesions: A review


1 Department of Oral and Maxillofacial Pathology, Drs Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram, Krishna District, Andhra Pradesh, India
2 Vishnu Dental College, Bhimavaram, West Godavari, Andhra Pradesh, India

Correspondence Address:
Soujanya Pinisetti
Department of Oral and Maxillofacial Pathology, Drs Sudha and Nageswara Rao Siddartha Institute of Dental Sciences Chinoutpally, Gannavaram, Krishna District - 521 286, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.131905

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Myofibroblasts (MFs) are modified fibroblasts that express features of smooth muscle differentiation and were first observed in granulation tissue during wound healing. These cells play a key role in physiologic and pathologic processes like wound healing and tumorigenesis. The presence of MFs has been reported in normal oral tissues and pathologic conditions like reactive lesions, benign tumors, locally aggressive tumors and malignancies affecting the oral cavity. This article briefly reviews the important hallmarks related to the discovery, characterization and tissue distribution of MFs in oral health and disease.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007