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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

CASE REPORT Table of Contents   
Year : 2013  |  Volume : 17  |  Issue : 2  |  Page : 261-265
Centroblastic variant of diffuse large B-cell lymphoma: Case report and review of literature

Department of Oral Pathology and Microbiology, A. J. Institute of Dental Sciences, Kuntikana, Mangalore, Karnataka, India

Correspondence Address:
Preethi B Nayak
Department of Oral Pathology and Microbiology, A. J. Institute of Dental Sciences, Kuntikana, N.H-17, Mangalore - 575 004, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.119749

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Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin's lymphoma (NHL) making up about approximately 30% of all NHL. Its occurrence in the mandible is very rare. Histopathologically, five variants of DLBCL have been recognized among which centroblastic variant is the one with better prognosis. We report a case of a 55 year-old patient who presented with a painless swelling in the lower right body of the mandible since 4 months. Incisional biopsy revealed NHL like features, confirmed by immunohistochemistry using CD45, CD20, and CD3 markers to be a DLBCL of centroblastic variant. Patient was treated with chemotherapy following which the lesion regressed completely with no further recurrences. Precise histological diagnosis is crucial for the clinical management and ultimately for the survival of the patient.

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