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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

ORIGINAL ARTICLE Table of Contents   
Year : 2013  |  Volume : 17  |  Issue : 2  |  Page : 195-200
HPV involvement in OSCC: Correlation of PCR results with light microscopic features

1 Department of Oral Pathology and Microbiology, M N D.A.V. Dental College, Tatul, Solan, Himachal Pradesh, India
2 Department of Oral Pathology and Microbiology, D.J. College of Dental Sciences and Research, Modinagar, Ghaziabad, Uttar Pradesh, India
3 Department of Oral Pathology and Microbiology, Faculty of Dentistry Jamia Mallia Islamia, Delhi, India
4 Department of Oral Pathology and Microbiology, Kalka Dental College, Meerut, India

Correspondence Address:
Rajbir Kaur Khangura
264-B, Bhai Randhir Singh Nagar, Ludhiana - 141 004, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-029X.119756

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Objectives: The study evaluated pathognomic histopathological features with the help of light microscopy for detecting the integration of human papillomavirus (HPV) (type 16 and 18) in oral squamous cell carcinoma (OSCC). Materials and Methods: Forty-five histopathologically diagnosed cases of OSCC were evaluated for the presence of E6/E7 protein of HPV (16 + 18) with the help of nested multiplex polymerase chain reaction. Both HPV-positive and -negative cases were evaluated for four histological features: Koilocytes, dyskeratosis, invasion, and alteration of collagen. Results: Fischer's exact test showed significant difference (P < 0.01%) for the presence of koilocytes and dyskeratosis, whereas no difference was observed for invasion and alteration in collagen between HPV-positive and -negative OSCC. Conclusion: The presence of koilocytes and dyskeratosis at light microscopic level can be used as a marker for the presence of HPV (type 16 and 18) in OSCC.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007