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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2013  |  Volume : 17  |  Issue : 2  |  Page : 156-162
Triology of nitric oxide, mast cell and stress in pathogenesis of oral lichen planus


1 Department of Oral Pathology and Microbiology, Bhojia Dental College, Budh, Baddi, Solan, Himachal Pradesh, India
2 Department of Oral Pathology and Microbiology, Subharti Dental College, Uttar Pradesh, India
3 Department of Prosthodontics and Implantology, Bhojia Dental College, Budh, Baddi, Solan, Himachal Pradesh, India
4 Department of Oral Medicine and Radiology, Subharti Dental College, Uttar Pradesh, India

Correspondence Address:
Charu Kapoor
Department of Oral Pathology and Microbiology Bhojia Dental College, Badii, Solan, Himachal Pradesh - 173 205
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.119741

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Introduction: Oral Lichen planus (OLP) is chronic, autoimmune, mucocutaneous disease. Numerous etiological factors have been proposed, but an authoritative and exact source of the disease has not been brought forward. Reactive nitrogen species (RNS), mast cell (MC) and stress are considered to play a key role in inflammation-mediated carcinogenesis generating nitric oxide (NO). Aim: To evaluate the salivary NO levels, mast cells and stress levels and to correlate them in pathogenesis of OLP. Materials and Methods: The study was conducted using saliva samples of patients. The study consisted of two groups: Group-I constituted the subjects with OLP group (n=25) and group II comprised the control group (n=25). The saliva of the patients was evaluated using Griess Reagent and Spectrophotometer, MC count done by using special stains, and stress levels measured using DASS Scale. Results: The difference between the means was found to be highly significant (P < 0.05). The intergroup comparison of optical density (OD) values, a mast cell count and stress level was found to be highly significant. Conclusion: Salivary NO, increase in mast cell count and stress has a definitive role in OLP pathogenesis.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007