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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2012  |  Volume : 16  |  Issue : 3  |  Page : 349-353
The sensitivity and specificity of computerized brush biopsy and scalpel biopsy in diagnosing oral premalignant lesions: A comparative study


1 Department of Oral Pathology, SIBAR Institute of Dental Sciences, Guntur, India
2 Department of Oral Surgery, Govt. Dental College, Vijayawada, Andhra Pradesh, India
3 Department of Oral Pathology, Sri Sai College of Dental Sciences, Srikakulam, Andhra Pradesh, India
4 Department of Oral Pathology, Navodaya Dental College, Raichur, Karnataka, India

Correspondence Address:
Sridhar G Reddy
Department of Oraland Maxillo Facial Pathology, SIBAR Institute of Dental Sciences, Takkellapadu, Guntur 522509, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.102482

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Background: The diagnosis of oral malignancy and epithelial dysplasia has traditionally been based upon histopathological evaluation of full thickness biopsy from lesional tissue. As many studies had shown that incisional biopsy could cause progression of the tumors, many alternative methods of collection of samples had been tested. Oral brush biopsy is a transepithelial biopsy where it collects cells from basal cell layer noninvasively. Aim: To assess the diagnostic accuracy of brush biopsy when compared to histopathology in a group of patients with features of potentially malignancy. Materials and Methods : In the present study, 60 cases of clinically diagnosed leukoplakia are selected and subjected to histopathology and brush biopsy. Results and Conclusion: Results showed that of 16 dysplasia cases confirmed by histopathology, only 12 were positively reported in oral brush biopsy. In 44 cases, the reports are same for histopathology and brush biopsy. The sensitivity of oral brush biopsy is 43.5% and specificity is 81.25% with a positive predictive value of 58.3%. Oral brush biopsy with molecular markers like tenascin and keratins can be an accurate diagnostic test.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007