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KNOW YOUR FIELD |
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| Year : 2012 | Volume
: 16
| Issue : 2 | Page : 306-307 |
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Undifferentiated pleomorphic sarcoma
Jeyanthi Premkumar, Sathyakumar Mayilvakanam, Yakob Martin, Karupur Thiagarajan Magesh
Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, SRM University, Potheri, Kanchipuram Dt, Tamilnadu, India
| Date of Web Publication | 27-Jul-2012 |
Correspondence Address:
Jeyanthi Premkumar
Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, SRM University, Potheri, Kanchipuram Dt, Tamilnadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-029X.99098
How to cite this article:
Premkumar J, Mayilvakanam S, Martin Y, Magesh KT. Undifferentiated pleomorphic sarcoma. J Oral Maxillofac Pathol 2012;16:306-7 |
How to cite this URL:
Premkumar J, Mayilvakanam S, Martin Y, Magesh KT. Undifferentiated pleomorphic sarcoma. J Oral Maxillofac Pathol [serial online] 2012 [cited 2019 Aug 20];16:306-7. Available from: http://www.jomfp.in/text.asp?2012/16/2/306/99098 |
 Clinical Features | |  |
A 42-year-old female patient presented a painless, firm mass on the hard palate involving the premaxilla region. The swelling was small in size initially which grew progressively to a size of 2 × 3 cm in a duration of 3 months.
| Histopathology | | |
- The section showed orthokeratinized stratified squamous epithelium in association with connective tissue exhibiting aggregates of spindle-shaped fibroblast-like cells streaming in interlacing fascicles and intersecting with cells from adjacent aggregates giving a storiform pattern, in 10× magnification [Figure 1].
 | Figure 1: Orthokeratinized stratified squamous surface epithelium and connective tissue shows bundles of spindle-shaped cells in a storiform pattern (10× magnification)
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- Connective tissue exhibits numerous aggregates of streaming interlacing fascicles at various foci of the section, in 10× magnification [Figure 2].
- Intersecting fascicles of plump spindle-shaped fibroblast-like cells exhibiting pleomorphism and hyperchromatism, in 40× magnification [Figure 3].
 | Figure 3: Malignant cells exhibiting pleomorphism and hyperchromatism (40× magnification)
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- The spindle-shaped cells show marked hyperchromatism, nuclear pleomorphism, and increased mitotic activity, under 40× magnification [Figure 4].
 | Figure 4: Plump spindle-shaped fibroblasts and increased mitosis (40× magnification)
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- Areas of hemorrhage and necrosis were found amidst the malignant connective tissue cells, under 10× magnification [Figure 5].
 | Figure 5: Areas of hemorrhage and necrosis were found amidst the malignant connective tissue cells
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- Immunohistochemistry was done with markers vimentin and CD68. Malignant cells showed strong positivity for vimentin and moderate positivity for CD68, as shown in [Figure 6] and [Figure 7], respectively.
 | Figure 6: Immunohistochemical picture showing strong positivity for vimentin
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 | Figure 7: Immunohistochemical picture showing moderate positivity for CD 68
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| Diagnosis | | |
Undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma).
| Conclusion | | |
- Storiform variant malignant fibrous histiocytoma mimics all poorly differentiated malignancies, and is identified by using immunohistochemical markers.
| Acknowledgment | | |
We thank Dr. Prathiba Ramani, MDS, Professor, Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]
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