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Year : 2012 | Volume
: 16
| Issue : 2 | Page : 306-307 |
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Undifferentiated pleomorphic sarcoma
Jeyanthi Premkumar, Sathyakumar Mayilvakanam, Yakob Martin, Karupur Thiagarajan Magesh
Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, SRM University, Potheri, Kanchipuram Dt, Tamilnadu, India
Date of Web Publication | 27-Jul-2012 |
Correspondence Address: Jeyanthi Premkumar Department of Oral and Maxillofacial Pathology, SRM Kattankulathur Dental College, SRM University, Potheri, Kanchipuram Dt, Tamilnadu India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-029X.99098
How to cite this article: Premkumar J, Mayilvakanam S, Martin Y, Magesh KT. Undifferentiated pleomorphic sarcoma. J Oral Maxillofac Pathol 2012;16:306-7 |
How to cite this URL: Premkumar J, Mayilvakanam S, Martin Y, Magesh KT. Undifferentiated pleomorphic sarcoma. J Oral Maxillofac Pathol [serial online] 2012 [cited 2019 Dec 6];16:306-7. Available from: http://www.jomfp.in/text.asp?2012/16/2/306/99098 |
Clinical Features | |  |
A 42-year-old female patient presented a painless, firm mass on the hard palate involving the premaxilla region. The swelling was small in size initially which grew progressively to a size of 2 × 3 cm in a duration of 3 months.
Histopathology | |  |
- The section showed orthokeratinized stratified squamous epithelium in association with connective tissue exhibiting aggregates of spindle-shaped fibroblast-like cells streaming in interlacing fascicles and intersecting with cells from adjacent aggregates giving a storiform pattern, in 10× magnification [Figure 1].
 | Figure 1: Orthokeratinized stratified squamous surface epithelium and connective tissue shows bundles of spindle-shaped cells in a storiform pattern (10× magnification)
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- Connective tissue exhibits numerous aggregates of streaming interlacing fascicles at various foci of the section, in 10× magnification [Figure 2].
- Intersecting fascicles of plump spindle-shaped fibroblast-like cells exhibiting pleomorphism and hyperchromatism, in 40× magnification [Figure 3].
 | Figure 3: Malignant cells exhibiting pleomorphism and hyperchromatism (40× magnification)
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- The spindle-shaped cells show marked hyperchromatism, nuclear pleomorphism, and increased mitotic activity, under 40× magnification [Figure 4].
 | Figure 4: Plump spindle-shaped fibroblasts and increased mitosis (40× magnification)
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- Areas of hemorrhage and necrosis were found amidst the malignant connective tissue cells, under 10× magnification [Figure 5].
 | Figure 5: Areas of hemorrhage and necrosis were found amidst the malignant connective tissue cells
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- Immunohistochemistry was done with markers vimentin and CD68. Malignant cells showed strong positivity for vimentin and moderate positivity for CD68, as shown in [Figure 6] and [Figure 7], respectively.
 | Figure 6: Immunohistochemical picture showing strong positivity for vimentin
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 | Figure 7: Immunohistochemical picture showing moderate positivity for CD 68
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Diagnosis | |  |
Undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma).
Conclusion | |  |
- Storiform variant malignant fibrous histiocytoma mimics all poorly differentiated malignancies, and is identified by using immunohistochemical markers.
Acknowledgment | |  |
We thank Dr. Prathiba Ramani, MDS, Professor, Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]
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