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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists

REVIEW ARTICLE Table of Contents   
Year : 2012  |  Volume : 16  |  Issue : 2  |  Page : 256-261
The use of salivary cytokines as a screening tool for oral squamous cell carcinoma : A review of the literature

1 Section of Pathology, The Gade Institute, University of Bergen; Centre for International Health, University of Bergen, Bergen, Norway
2 Section of Pathology, The Gade Institute, University of Bergen, Bergen, Norway
3 Section of Pathology, The Gade Institute, University of Bergen; Department of Pathology, Haukeland University Hospital, Bergen, Norway

Correspondence Address:
Tarig A Osman
Section of Pathology, The Gade Institute, University of Bergen, N-5021 Bergen
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Source of Support: Study was supported by University of Bergen and Norwegian Educational Loan Fund, through the Qouta program., Conflict of Interest: None

DOI: 10.4103/0973-029X.99083

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Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer. The 5-year survival rate has remained below 50% over the last two decades, and new tools for early diagnosis are needed. Saliva has been used for diagnosis of several systemic diseases, and its use for diagnosis of OSCC has been sought extensively. Among the many salivary analytes for diagnosis of OSCC, accumulating evidences indicate the possibility of using salivary cytokines. Overproduction of proinflammatory, proangiogenic cytokines by OSCC cells has been reported, and their role in tumor progression and angiogenesis is well established. However, many inflammatory conditions and immunological diseases could affect the levels of cytokines in serum and saliva. This article has reviewed publications in this matter, and some strengths and weaknesses have been pointed out. Conclusively, large-scale investigations are required for validation of the use of salivary cytokines for diagnosis of OSCC, with consideration to the influential role of periodontal inflammation in their levels.

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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007