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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2012  |  Volume : 16  |  Issue : 2  |  Page : 183-188
Expression of epithelial growth factor receptor in oral epithelial dysplastic lesions


1 Department of Oral and Maxillofacial Pathology, Priyadarshini Dental College and Hospital, Chennai, India
2 Department of Oral and Maxillofacial Pathology, Vishnu Dental College and Hospital, Bhimavaram, Andhra Pradesh, India

Correspondence Address:
Manickam Rajakili Chockalingam Rajeswari
C 111, Karthikeyan Road, Periyar Nagar, Chennai- 600 082
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.98496

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Aim: The aim of the study was to assess the expression of epithelial growth factor receptor (EGFR) in normal oral mucosa and varying grades of oral epithelial dysplasia (OED) and to correlate these findings, with clinicopathologic features and findings on routine hematoxylin and eosin-stained (H and E) sections. Materials and Methods: Twenty-nine formalin-fixed, paraffin-embedded blocks of various grades of OED and 10 normal mucosa were stained with routine H and E and immunostained with EGFR by avidin-biotin method. Results: The results showed a significant increase in the staining reactions in varying grades of dysplasia as compared with normal mucosa. Conclusion: EGFR can be considered as an early marker of a cell proliferation and maturation as well as early marker of epithelial dysplasia and onset of cancer in oral dysplasia. However, further studies with a larger sample size and continuous followup is suggested to determine its role and significance precisely.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007