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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
REVIEW ARTICLE Table of Contents   
Year : 2012  |  Volume : 16  |  Issue : 1  |  Page : 73-78
Potential role of septins in oral carcinogenesis: An update and avenues for future research


Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, India

Correspondence Address:
Rooban Thavarajah
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai 600 119
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.92977

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Septins belong to the GTPase superclass of conserved proteins and have been identified to play a role in diverse aspects of cell biology, from cytokinesis to the maintenance of cellular morphology. At least 14 septins have been identified in humans. With their complex patterns in gene expressions and interaction, it has been reported that alterations in septin expression are observed in human diseases. Although much is not known about the role of human septins in oral carcinogenesis, circumstantial evidence does indicate that it may play a major role. This review intends to summarize the basis of septin biology, with the focus being on the evidence for septin involvement in human oral cancer.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007