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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2011  |  Volume : 15  |  Issue : 2  |  Page : 182-186
A study of antifungal drug sensitivity of Candida isolated from human immunodeficiency virus infected patients in Chennai, South India


Department of Oral Pathology, Thai Moogambigai Dental College, Ragas Dental College, Chennai, India

Correspondence Address:
Nadeem Jeddy
Department of Oral Pathology, Thai Moogambigai Dental College and Hospital, Golden George Nagar, Mogappair, Chennai - 600 107
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.84490

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Background: The purpose of this study was to study the drug sensitivity pattern of Candida seen in HIV seropositive patients in Chennai, South India. Materials and Methods: 36 oral rinse samples were collected from HIV seropositive individuals with (21 patients) and without (15 patients) clinical candidiasis. The type of Candidiasis, quantitative estimation, differentiation of candida species and antifungal susceptibility testing was done using different tests. Results: In the 21 patients with candidiasis, pseudomembranous type predominated with low CD4 counts and high colony forming units. Antifungal Drug sensitivity test revealed resistance to fluconazole which is attributed to long term exposure to the drug. Conclusion: The results of the study confirm the hypothesis that candidal species can be isolated in HIV positive patients with clinical candidiasis. In HIV infection there are fluconazole resistant candida species emerging mainly due to long term exposure to the drug.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
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