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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2011  |  Volume : 15  |  Issue : 2  |  Page : 148-153
Proliferation and apoptosis markers in oral submucous fibrosis


Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, India

Correspondence Address:
K Ranganathan
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, 2/102, East Coast Road, Uthandi, Chennai-600 119
India
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Source of Support: Department of Biotechnology, Ministry of Science and Technology, Government of India, Sanction number BT/PR/1592/MED/09/249/99, Conflict of Interest: None


DOI: 10.4103/0973-029X.84478

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Background: Premalignant/potentially malignant-oral lesions and conditions such as oral submucous fibrosis are known to transform into oral cancer. The malignant transformation is often associated with changes at the genetic level that in turn is reflected by the altered expression of proteins related to cell cycle, proliferation, and apoptosis. Aim: To evaluate the expression of p53, Ki67 (MIB), bcl2, and bax in oral submucous fibrosis and oral squamous cell carcinoma. Materials and Methods: To assess the immunohistochemical expression of p53, Ki67 (MIB), bcl2, and bax in 50 cases of oral submucous fibrosis (OSF) and ten each of normal and oral squamous cell carcinoma (OSCC). Results: The labeling indices (LI) of OSF and OSCC were comparable for p53 and Ki67.The p53 LI ranged from 7.9 to 71.9 in OSF and 65.2 to 85.9 in OSCC, and for Ki67 it ranged from 4.39 to 43.23, 18.35 to 42.33, respectively. Conclusion: The p53, Ki67, and bax profiles of OSF and OSCC were altered compared to the normal and these markers could be used as surrogate markers of malignant transformation in OSF.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007