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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
CASE REPORT Table of Contents   
Year : 2011  |  Volume : 15  |  Issue : 1  |  Page : 39-45
Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases


1 Department of Oral Pathology, Chennai Dental Research Foundation, Chennai, Tamil Nadu, India
2 Department of Oral Pathology, Ragas Dental College and Hospitals, Chennai, India
3 Department of Oral Pathology, Chennai Dental Research Foundation, Chennai, India
4 Department of Oral Pathology, YRG Care, Chennai, India

Correspondence Address:
S Balasundaram
Department of Oral and Maxillofacial Pathology, Chennai Dental Research Foundation, No 56, Dr. Radhakrishnan Salai, Mylapore, Chennai - 600 004, Tamil nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.80024

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Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007