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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
ORIGINAL ARTICLE Table of Contents   
Year : 2008  |  Volume : 12  |  Issue : 1  |  Page : 2-7
Clinico-pathological correlation of micronuclei in oral squamous cell carcinoma by exfoliative cytology


1 Department of Oral Pathology and Microbiology, V.S.P.M.'s Dental College and Research Centre, Digdoh Hills, Hingna Road, Nagpur, India
2 Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Devendra H Palve
Department of Oral Pathology and Microbiology, V.S.P.M.'s Dental College and Research Centre, Digdoh Hills, Hingna Road, Nagpur, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.42189

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Oral squamous cell carcinoma accounts for 90% to 95% of all oral malignancies. Though its diagnosis seldom presents difficulty, it is the cancer staging and histopathological grading that are important to prognostication; and micronuclei are good prognostic indicators. Micronucleus frequencies in oral exfoliated cells stained with papanicolaou stain were counted and correlated with the histopathological grades and clinical stages of squamous cell carcinoma patients. They were also compared with healthy control subjects. Micronuclei (MN) frequencies were found higher in squamous cell carcinoma patients than in control subjects. MN frequencies were also found to be raised with increasing histological grades of squamous cell carcinoma.


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Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow
Online since 15th Aug, 2007