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An Official Publication of the Indian Association of Oral and Maxillofacial Pathologists


 
CASE REPORT Table of Contents   
Year : 2007  |  Volume : 11  |  Issue : 1  |  Page : 38-41
 

Aneurysmal bone cyst of the mandible: Report of a case and review of the literature


1 Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, India
2 Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College, Chennai, India

Correspondence Address:
Srinivasa Prasad
Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College and Hospital, Alapakkam Main Road, Maduravoyal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-029X.33964

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   Abstract 

Aneurysmal bone cyst (ABC) is an uncommon non-neoplastic lesion of the bones, usually affecting the long bones and spine. The rare jaw lesions are encountered in the body and ramus of the mandible. Commonly reported in the second and third decades of life, ABC's are characterized by a rapid growth pattern with resultant bony expansion and facial asymmetry. Surgical management usually consists of surgical curettage or resection. This paper describes a case of ABC in a 21-year-old female, that presented as an expansile bony mass in the parasymphyseal region. A brief review of existing literature on ABC is also made.


Keywords: Aneurysmal bone cyst, jaw cyst, jaw neoplasm, pseudocyst


How to cite this article:
Prasad S, Raghaviah AM, Sharma N, Einstein A, Saraswathi T R. Aneurysmal bone cyst of the mandible: Report of a case and review of the literature. J Oral Maxillofac Pathol 2007;11:38-41

How to cite this URL:
Prasad S, Raghaviah AM, Sharma N, Einstein A, Saraswathi T R. Aneurysmal bone cyst of the mandible: Report of a case and review of the literature. J Oral Maxillofac Pathol [serial online] 2007 [cited 2017 Jul 25];11:38-41. Available from: http://www.jomfp.in/text.asp?2007/11/1/38/33964



   Introduction Top


The World Health Organization defines aneurysmal bone cyst (ABC) as "a benign tumour-like lesion with an expanding osteolytic lesion consisting of blood-filled spaces of variable size separated by connective tissue septa containing trabeculae or osteoid tissue and osteoclast giant cells". [1] Although benign, ABC can be a rapidly growing and destructive bone lesion. The expansile nature of this lesion can cause pain, swelling, deformity, perforation or disruption of cortical plates, neurological symptoms (depending on its location) and pathologic fracture.

Jaffe and Lichtenstein were the first to recognize ABC as an intraosseous, osteolytic lesion chiefly affecting the metaphyseal region of long bones and vertebrae. [2] Bernier and Bhaskar described the first case of ABC in the jaws. [3] ABCs are most commonly found in the long bones and the vertebral column [4] . Only 1.9% of all ABCs occur in the jaws, representing 1.5% of all nonodontogenic cysts. [5] ABCs are found more frequently in the mandible than the maxilla (3:1) with preponderance for the body, ramus and angle of the mandible. [6] Involvement of other bones of the face such as zygoma and zygomatic arch has also been reported. [7],[8],[9] No sexual predilection has been established, but an age distribution toward young adulthood has been observed. [4] ABCs display variable aetiopathogenic, histological and radiographic characteristics.


   Case Report Top


A 21-year-old female patient reported to the outpatient department with the complaint of a hard, tender swelling in the right lower back teeth region since months; with associated altered sensation in the right lower lip. She gave history of a small swelling that had started three months back and had since then increased in size with associated pain for the past one month. She gave history of facial trauma a year ago. The patient had history of irregular menstrual cycle and was under medication and also had a breast lump that regressed after taking medication. The patient had no significant family history.

Clinical examination was normal except for apparent facial disharmony with a firm, smooth, tender, diffuse swelling of 2.5 x 2 cms in the right mandibular parasymphyseal region. Intraorally, the expansion was evident in both the lingual and buccal vestibular regions with intact mucoperiosteal tissues [Figure - 1]. There was no sinus opening or any discharge. Teeth in the involved areas were vital as checked by both thermal and electrical pulp testing.

Radiographic examination showed a unilocular radiolucency extending from the root of the right central incisor to the distal aspect of the root of right second premolar. Superiorly, the radiolucency was seen extending between the canine and premolars. Resorption of roots of the involved teeth was not observed. There was no discontinuity of the lower border [Figure - 2]. Routine haematologic investigations were non-contributory. On aspiration, about 2 ml of blood was obtained.

Considering the recent history of trauma, clinical presentation, radiographic features and positive blood aspiration, a provisional diagnosis of aneurysmal bone cyst was made and excisional biopsy of the lesion was planned under general anesthesia.

An intraoral crevicular incision was extended up to first molar with a vertical release incision in the midline. The buccal cortex was exposed which was egg-shell thin, but not perforated. The lingual cortex was also expanded. A bluish-brown, soft, vascular connective tissue was exposed on peeling the outer cortical plate [Figure - 3]. The tissue was totally curetted out, until there was no bleeding, indicating complete removal [Figure - 4]. The incision was closed with a 3-0 catgut. The patient's postoperative course was uneventful and the wound healed normally.

The excised specimen was sent for histopathological examination. Histological sections from the specimen revealed multiple blood-filled sinusoidal spaces surrounded by fibrous tissue, with the presence of cluster of giant cells. Mature and immature bony trabeculae and hemorrhage and hemosiderin deposits were observed [Figure - 5],[Figure - 6],[Figure - 7],[Figure - 8],[Figure - 9]. The histologic picture was consistent with aneurysmal bone cyst. The patient is on regular follow-up for the last one year and is asymptomatic.


   Discussion Top


The true etiology of ABC is unknown. Most believe that ABC are the result of a vascular malformation within the bone. The cause of the malformation is however a topic of controversy. Three theories concerning the cause and pathogenesis of ABC have been proposed; possible traumatic origin resulting in subperiosteal or intra-medullary hemorrhage with misguided reparative processes; [3] altered hemodynamic state leading to a dilated congested vascular bed, causing resorption and erosion of bone with expansion of the lesion; and a secondary phenomenon that occurs in a primary osseous lesion. In our case, trauma could have contributed to the development of the lesion. Panoutsakopoulos et al.[10] described three cases of ABC with chromosomal anomalies; band 16q22 being involved in all three patients. Similar findings were reported by Herens et al .[11] Familial incidence of ABC has also been reported in the literature. [12],[13],[14]

The radiographic features are not pathognomonic and there is no consensus in the literature in this regard. The "blown-out" appearance in radiographs gives the appearance of a "bone cyst". The lesion may appear unicystic or as a unilocular, multilocular (soap-bubble or honeycomb) or moth-eaten radiolucency, causing expansion, perforation or destruction of the bony cortices. There may also be an associated periosteal reaction with reactive new bone formation, resulting in a peripheral sclerotic border in some cases. [8],[9],[15],[16],[17] Our case presented as a unilocular radiolucency; however, resorption of roots of the involved teeth was not observed in spite of the close proximity of the radiolucency to the roots.

Histologically, ABC consists of a fibrous connective tissue stroma with numerous blood filled caverns of sinusoids, multinucleated giant cells and osteoid. Hemosiderin is present in variable amounts and osteoid and bone formation are variable. [17] Since a normal epithelial lining is lacking, the lesion is also referred to as pseudocyst. The histologic appearance in our case was consistent with the abovementioned features.

The clinical course of the ABC is inconsistent, ranging from a self-limiting lesion to an aggressive, rapidly destructive lesion mimicking malignancy. [6],[15],[18],[19] Treatment of ABC is usually directed towards complete removal of the lesion. Before entering the lesion, it should be adequately exposed to enable a rapid curettage to be done. Curettage may prove difficult at times since the lesions are often multilocular and may be divided by multiple bony septae. Massive bleeding may be encountered as soon as the lesion is entered and will continue until complete curettage is accomplished. Continued bleeding after completion of the procedure indicates incomplete curettage. In such cases, irrigation of the cavity enables identification of the source of bleeding and prompt curettage. The role of such factors explains the multitude of treatment modalities available for ABC; [20] no treatment, [19],[20],[21],[22],[23] simple curettage, [24] cryotherapy, [20],[26],[27] excision, block resection and microvascular bone grafting, [24] therapeutic embolization and open packing. [25]

Recurrence of jaw lesion, although uncommon, has been attributed to inadequate access and thus incomplete removal of the lesion, [5],[8],[17],[18],[21] for which block resection is advocated. Our lesion was not a recurrence and there was no evidence of any residual lesion. This factor led us to opting for curettage as the treatment of choice.

Filling the defect with bone grafts is not required as bone repair is rather rapid. [19],[22],[23] Use of radiation has not been advocated as it may fail to arrest the lesion and can result in sarcomatous changes. [28],[29],[30]


   Acknowledgments Top


The authors thank Dr. R.S. Neelakandan, Professor and Head, Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai for his critical review and comments on the manuscript.

 
   References Top

1.Kramer IR, Pindburg JJ, Shear M (1992): In: Histological typing of odontogenic tumours, 2 nd edn. Berlin: Springer-Verlag; p. 32.  Back to cited text no. 1    
2.Jaffe HL, Lichtenstein L (1942): Solitary unicameral bone cyst with emphasis on the roentgen picture, the pathologic appearance and pathogenesis, Arch Surg, 44:1004-25.  Back to cited text no. 2    
3.Bernier JL, Bhaskar SN (1958): Aneurysmal bone cysts of the mandible oral Surg Oral Med Oral Pathol, 11:1018-28.  Back to cited text no. 3    
4.Giddings NA, Kennedy TL, Knipe KL, Levine HL, Smith JD (1989): Aneurysmal bone cyst of the mandible, Arch Otolaryngol Head Neck Surg, 115:865-70.  Back to cited text no. 4    
5.Eldeeb M, Sedano HO, Waite DE (1980): Aneurysmal bone cyst of the jaws. Report of a case associated with fibrous dysplasia and review of the literature, Int J Oral Surg, 9:301-11.  Back to cited text no. 5    
6.Trent C, Byl FM (1993): Aneurysmal bone cyst of the mandible, Ann Otol Rhinol Laryngol, 102:917-24.  Back to cited text no. 6    
7.Eveson, JW, Moos KF, MacDonald (1978): Aneurysmal bone cyst of the zygomatic arch, Br J Oral Surg, 15:259-64.  Back to cited text no. 7    
8.Struthers PM (1984): Shear Aneurysmal bone cyst of the jaws, Clinicopathological features, Int J Oral Surg, 13:85.  Back to cited text no. 8    
9.Struthers PM (1984): Shear: Aneurysmal bone cyst of the jaws. Pathogenesis, Int J Oral Surg, 13:92.  Back to cited text no. 9    
10.Panoutsakopoulos G, Pandis N, Kyriazoglou I, Gustafson P, Mertens F, Mandahl N (1999): Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts, Genes Chromosom Cancer, 26:265-6.  Back to cited text no. 10    
11.Herens C, Thiry A, Dresse MF, Born J, Flagothier C, Vanstraelen G, et al . (2001): Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurismal bone cysts, Cancre Gene Cytogene, 127:83-4.  Back to cited text no. 11    
12.Vicenzi G (1981): Familial incidence in two cases of aneurysmal bone cyst, Ital J Orthop Traumatol, 7:251-3.  Back to cited text no. 12    
13.Power RA, Robbins PD, Wood DJ (1996): Aneurysmal bone cyst in monozygotic twins: A case report, J Bone Joint Surg BR, 78:323-4.  Back to cited text no. 13    
14.Leithner A, Windhager R, Kainberger F, Lang S (1998): A case of aneurysmal bone cyst in father and son. Eur J Radiol, 29:28-30.  Back to cited text no. 14    
15.Kalantar Motamedi MH, Khodayar A (1993): Aneurysmal bone cyst mimicking a malignancy, J Oral Maxillofac Surg, 51:691.  Back to cited text no. 15    
16.Laskin DM (1985): Oral and maxillofacial surgery, Vol 2. CV Mosby, St Louis, p. 477-8.  Back to cited text no. 16    
17.Shafer WG, Hine MK, Levy BM (1983): A textbook of oral pathology, Saunders, Philadelphia; p. 149-52.  Back to cited text no. 17    
18.Hardee PS, Whear NM, Morgan PR (1992): Aneurysmal bone cyst of the maxilla-an association with tooth resorption, J Cranio Maxillofac Surg, 20:266-9.  Back to cited text no. 18    
19.Hernandez GA, Castro A, Castro G, Amador E (1993): Aneurysmal bone cyst versus hemangioma of the mandible. Report of a long-term follow-up of a self-limiting case oral Surg Oral Med Oral Pathol, 76:790-.  Back to cited text no. 19    
20.Marcove RC, Sheth DS, Takemoto S (1995): The treatment of aneurysmal bone cyst, Clin Orthop, 311:157-63.  Back to cited text no. 20    
21.Motamedi MH, Yazdi E (1994): Aneurysmal bone cysts of the jaws: Analysis of 11 cases. J Oral Maxillofac Surg, 52:471-5.  Back to cited text no. 21    
22.Kalantar Motamedi MH (1998): Aneurysmal bone cysts of the jaws: Clinicopathological features, radiographic evaluation and treatment analysis of 17 cases, J Cranio Maxillofac Surg, 26:56-62.  Back to cited text no. 22    
23.McQueen MM, Chalmers J, Smith GD (1985): Spontaneous healing of aneurysmal bone cysts. A report of two cases, J Bone Joint Surg Br, 67(2):310-2.  Back to cited text no. 23    
24.Schreuder HW, Veth RP, Pruszczynski M (1997): Aneurysmal bone cysts treated by curettage, cryotherapy and bone grafting, J Bone Joint Surg Br, 79(1):20-5.  Back to cited text no. 24    
25.Motamedi MH (2002): Destructive aneurysmal bone cyst of the mandibular condyle: Report of a case and review of the literature, J Oral Maxillofac Surg, 60:1357-61.  Back to cited text no. 25    
26.Malawer MM, Marks MR, McChesney D (1988): The effect of cryosurgery and polymethylmethacrylate in dogs with experimental bone defects comparable to tumor defects, Clin Orthop Relat Res, 226:299-310.  Back to cited text no. 26    
27.Marcove RC (1982): A 17-year review of cryosurgery in the treatment of bone tumors, Clin Orthop Relat Res, 163:231-4.  Back to cited text no. 27    
28.Cohan W (1984): Sarcoma arising in irradiated bone, Cancer, 1:3.  Back to cited text no. 28    
29.Cole L (1965): Radiation carcinogenesis: The sequence of events, Science, 150:1782.  Back to cited text no. 29    
30.Eisenbud L, Attie J, Garlick J (1987): Aneurysmal bone cyst of the mandible oral Surg Oral Med Oral Pathol, 64:202.  Back to cited text no. 30    


    Figures

  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5], [Figure - 6], [Figure - 7], [Figure - 8], [Figure - 9]



 

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    Abstract
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    Case Report
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